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Jiangsu, China
Contact Person Linda He
Tel: 0519-88122965 13775180513
Email: linda@huarenchem.com Cao Jing
Tel: 0519-88170087 13915040643
Email: info@huarenchem.com Amy Zhou
Tel: 0519-88103998 13646148298
Email: amy.zhou@huarenchem.com Miss Yu
Tel: 0519-88100916 13775081323
Email: ylp@huarenpharm.com
Fax: ++86 519 8810 4456
Products | APIs
Product Name
Sirolimus
CAS#
53123-88-9
Synonyms
Rapamycin
中文名
雷帕霉素; 西罗莫司
Molecular Formula
C51H79NO13
Description
Biochem/physiol Actions
Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
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